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The Effect of Cachexia on the Prognosis of Pancreatic Cancer Patients
https://doi.org/10.57457/00000004
https://doi.org/10.57457/00000004027a09ee-bbd6-4e99-9366-fd6355661d2d
| 名前 / ファイル | ライセンス | アクション |
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本文 (908.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2022-09-27 | |||||||||
| タイトル | ||||||||||
| タイトル | The Effect of Cachexia on the Prognosis of Pancreatic Cancer Patients | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | cachexia | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | pancreatic cancer | |||||||||
| キーワード | ||||||||||
| 言語 | en | |||||||||
| 主題Scheme | Other | |||||||||
| 主題 | prognostic factor | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.57457/00000004 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 |
三浦 聖子
× 三浦 聖子
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| 著者（英） | ||||||||||
| 姓名 | Seiko Miura | |||||||||
| 言語 | en | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Purpose: Cachexia is a syndrome characterized by physical wasting owning to reduced food intake and abnormal metabolism. The relationship between cachexia and prognosis of patients with pancreatic cancer remains unclear. This study aimed to elucidate the effect of cachexia on the survival of patients with pancreatic cancer. Methods: A total of 106 patients with pancreatic cancer were enrolled in this study. We divided the participants into cachexia group and non-cachexia group as per the diagnostic criteria of the European Society for Clinical Nutrition and Metabolism 2010 guidelines. The Kaplan-Meier survival curves between the two groups were compared using the log-rank test, and the Cox proportional hazard model was applied to calculate the hazard ratio (HR) of death caused by pancreatic cancer after adjustment for potential confounding factors. Results: At the time of cancer diagnosis, the number of cachexic and non-cachexia patients was 29 and 77, respectively. There were significant differences in body weight, body metabolic index, total lymphocyte count, albumin, and cholinesterase between the cachexia and non-cachexia groups. The cachexia group had a shorter survival rate than the non-cachexia group (50% survival time was 295 days and 662 days, respectively), and the survival difference was statistically significant (p=0.001). After adjusting for age, sex, and clinical stage, cachexia still significantly increased the risk of death caused by pancreatic cancer (HR: 1.648; 95% confidence interval: 1.009–2.692). Conclusions: A significant association was found between cachexia at the time of diagnosis and prognosis in patients with pancreatic cancer. This finding indicates that cachexia at diagnosis is a useful prognostic factor in patients with pancreatic cancer. |
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| 書誌情報 |
金沢医科大学雑誌 en : Journal of Kanazawa Medical University 巻 45, 号 3, p. 29-34, 発行日 2020-12 |
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| 出版者 | ||||||||||
| 出版者 | 金沢医科大学医学会 | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | PISSN | |||||||||
| 収録物識別子 | 0385-5759 | |||||||||
| 著者版フラグ | ||||||||||
| 出版タイプ | VoR | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||
