{"created":"2023-06-20T14:02:29.444323+00:00","id":15,"links":{},"metadata":{"_buckets":{"deposit":"15a219cf-4125-481c-aec6-3dd4bb83752c"},"_deposit":{"created_by":6,"id":"15","owners":[6],"pid":{"revision_id":0,"type":"depid","value":"15"},"status":"published"},"_oai":{"id":"oai:kanazawa-med.repo.nii.ac.jp:00000015","sets":["1:13:15"]},"author_link":["95"],"control_number":"15","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"34","bibliographicPageStart":"25","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"金沢医科大学雑誌"},{"bibliographic_title":"Journal of Kanazawa Medical University","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筆者はこれまで四半世紀に渡って糖化蛋白質研究を遂行し，体内では色々な経路から様々な終末糖化産物 (advanced glycation end-products, AGEs) が生成されていることを明らかにしてきた。近年，生活習慣病の原因物質としてAGEsが注目されており，このAGEsの作用を抑えることが病気の予防や治療へ導くと考えられるが，AGEsは反応する糖/カルボニル化合物の種類によっても様々な構造のものが存在し，疾患の原因となるAGEsの絞り込みは困難である。筆者らはブドウ糖/果糖代謝中間体であり，三炭糖のglyceraldehydeに由来する細胞毒性の強いAGEsが，生活習慣病と強く関連していることを明らかにし，toxic AGEs (TAGE) という概念を提唱している。また，現代の食習慣のひずみ (砂糖や果糖ブドウ糖液糖，食事性AGEsの習慣的過剰摂取) から，体内ではTAGEの生成・蓄積が増加している。実際に糖尿病のみならず，非糖尿病においても血中TAGEレベルの上昇がみられており，体内でのTAGEの生成・蓄積が生活習慣病の発症・進展と強く相関していることが示されている。本総説ではAGEsの中でも特に，「生活習慣病予防および健康寿命延伸における新規ターゲットTAGE」に関する研究結果について述べる。","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者（英）","attribute_value_mlt":[{"names":[{"name":"Masayoshi Takeuchi","nameLang":"en"}]}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.57457/00000009","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢医科大学医学会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0385-5759","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹内 正義","creatorNameLang":"ja"},{"creatorName":"タケウチ マサヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-21"}],"displaytype":"detail","filename":"46(2)25-34.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://kanazawa-med.repo.nii.ac.jp/record/15/files/46(2)25-34.pdf"},"version_id":"3d53191d-9dfc-4000-a4dc-0232fd1ffd9f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"毒性終末糖化産物","subitem_subject_scheme":"Other"},{"subitem_subject":"toxic AGEs (TAGE)","subitem_subject_scheme":"Other"},{"subitem_subject":"新規ターゲット","subitem_subject_scheme":"Other"},{"subitem_subject":"生活習慣病","subitem_subject_scheme":"Other"},{"subitem_subject":"健康寿命","subitem_subject_scheme":"Other"},{"subitem_subject":"advanced glycation end-products (AGEs)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"new target","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lifestyle-related diseases (LSRD)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"healthy life expectancy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"生活習慣病予防および健康寿命延伸における新規ターゲットToxic AGEs (TAGE)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生活習慣病予防および健康寿命延伸における新規ターゲットToxic AGEs (TAGE)","subitem_title_language":"ja"},{"subitem_title":"Toxic AGEs (TAGE) as a New Target in the Prevention of Lifestyle-Related Diseases and Prolongation of Healthy Life Expectancy","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"6","path":["15"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-09-27"},"publish_date":"2022-09-27","publish_status":"0","recid":"15","relation_version_is_last":true,"title":["生活習慣病予防および健康寿命延伸における新規ターゲットToxic AGEs (TAGE)"],"weko_creator_id":"6","weko_shared_id":-1},"updated":"2023-08-31T06:07:56.637826+00:00"}