{"created":"2024-03-29T00:37:04.846480+00:00","id":2000127,"links":{},"metadata":{"_buckets":{"deposit":"784964e7-a75a-4d6b-b56c-a9eabe79efea"},"_deposit":{"created_by":5,"id":"2000127","owner":"5","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"2000127"},"status":"published"},"_oai":{"id":"oai:kanazawa-med.repo.nii.ac.jp:02000127","sets":["1:1711524529114:1711524893657"]},"author_link":[],"control_number":"2000127","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"37","bibliographicPageStart":"35","bibliographicVolumeNumber":"49"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A 12-year-old Japanese boy presented with epigastric pain and swelling of the neck. Biopsy of the cervical lymph node and the bone marrow showed diffuse proliferation of lymphoblastic cells with precursor T-cell immunophenotypes. The patient was diagnosed with stage IV T-lymphoblastic lymphoma (T-LBL) and complete remission was successfully achieved after induction chemotherapy without any adverse events. At 10 months after diagnosis, he presented with an abrupt onset of transfusion-refractory thrombocytopenia during maintenance therapy. Bone marrow examinations revealed hypoplastic marrow with phagocytosis of the blood cells by multinucleated giant cells with foamy cytoplasm and a diagnosis of hemophagocytic lymphohistiocytosis (HLH) was confirmed. No evidence of T-LBL relapse was found by positron emission tomography. He progressed to severe bone marrow failure and underwent allogeneic stem cell transplantation (SCT) from his human leukocyte antigen (HLA)-matched brother. He achieved complete remission with partial hematological recovery. Unfortunately, the patient died from relapsed T-LBL at 6 months after SCT. The onset of HLH during childhood cancer therapy is extremely rare, but these conditions often develop chemoresistance resulting in a lethal outcome. Therefore, they may require more intensive myeloablative therapy with stem cell rescue.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_full_name_3":{"attribute_name":"著者（英）","attribute_value_mlt":[{"names":[{"name":"Naoki Okada","nameLang":"en"}]},{"names":[{"name":"Reiko Fujisawa","nameLang":"en"}]},{"names":[{"name":"Yutaka Saikawa","nameLang":"en"}]},{"names":[{"name":"Hitoshi Sato","nameLang":"en"}]}]},"item_10001_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.57457/0002000127","subitem_identifier_reg_type":"JaLC"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢医科大学医学会","subitem_publisher_language":"ja"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2436-6994","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田 直樹","creatorNameLang":"ja"},{"creatorName":"オカダ ナオキ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"藤澤 麗子","creatorNameLang":"ja"},{"creatorName":"フジサワ レイコ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"犀川 太","creatorNameLang":"ja"},{"creatorName":"サイカワ ユタカ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"佐藤 仁志","creatorNameLang":"ja"},{"creatorName":"サトウ ヒトシ","creatorNameLang":"ja-Kana"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-01"}],"displaytype":"detail","fileDate":[{"fileDateType":"Issued","fileDateValue":"2024-04-01"}],"filename":"49(1)35-37.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","url":"https://kanazawa-med.repo.nii.ac.jp/record/2000127/files/49(1)35-37.pdf"},"version_id":"e09c4127-817a-41da-833b-ecb73254b08a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"hemophagocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lymphohistiocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"T-lymphoblastic lymphoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hemophagocytic Lymphohistiocytosis during the Treatment of T-lymphoblastic Lymphoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hemophagocytic Lymphohistiocytosis during the Treatment of T-lymphoblastic Lymphoma","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"5","path":["1711524893657"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-03-29"},"publish_date":"2024-03-29","publish_status":"0","recid":"2000127","relation_version_is_last":true,"title":["Hemophagocytic Lymphohistiocytosis during the Treatment of T-lymphoblastic Lymphoma"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2024-04-01T04:29:17.038476+00:00"}