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Development of a Novel Bioabsorbable Semi-Rigid Annuloplasty Ring for Growth-Adaptive Pediatric Atrioventricular Valve Repair: Design and Mechanical Testing
https://doi.org/10.57457/0002000277
https://doi.org/10.57457/0002000277efc79fe7-162b-423c-a471-365c0127d7f4
| 名前 / ファイル | ライセンス | アクション |
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本文 (2.2 MB)
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| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2026-03-30 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Development of a Novel Bioabsorbable Semi-Rigid Annuloplasty Ring for Growth-Adaptive Pediatric Atrioventricular Valve Repair: Design and Mechanical Testing | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | pediatric cardiac surgery | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | annuloplasty ring | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | biodegradable polymer | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | PLA-PCL copolymer | |||||||||||||
| キーワード | ||||||||||||||
| 言語 | en | |||||||||||||
| 主題Scheme | Other | |||||||||||||
| 主題 | valve repair | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| ID登録 | ||||||||||||||
| ID登録 | 10.57457/0002000277 | |||||||||||||
| ID登録タイプ | JaLC | |||||||||||||
| 著者 |
安藤 誠
× 安藤 誠
× 西野 貴子
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| 著者（英） | ||||||||||||||
| 姓名 | Makoto Ando | |||||||||||||
| 言語 | en | |||||||||||||
| 著者（英） | ||||||||||||||
| 姓名 | Takako Nishino | |||||||||||||
| 言語 | en | |||||||||||||
| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Purpose: Pediatric atrioventricular valve (AVV) repair remains challenging because conventional annuloplasty rings restrict annular growth. An ideal pediatric ring should provide temporary mechanical support, controlled biodegradation, and compatibility with tissue remodeling. This study aimed to design and evaluate a novel semi-rigid annuloplasty ring composed entirely of biodegradable polymers, capable of maintaining early annular geometry while permitting physiological growth. Methods: A bi-layered annuloplasty ring was fabricated with an inner core of poly-L-lactic acid (PLA) and ε-caprolactone (PCL) copolymer films and an outer microporous PLA–PCL or PCL sheath to promote tissue integration. Twenty 16-mm prototypes were produced by varying the PLA–PCL ratio, core layering, and inclusion of polyglycolic acid (PGA) felt. Mechanical performance was assessed under uniaxial tensile loading to 3 N in the septo-lateral (S–L) direction, cyclic testing (500 cycles), and needle penetration analysis to evaluate suture handling. In vitro degradation testing was conducted by immersing samples in phosphate-buffered saline (PBS) at 37 °C for 28 days to simulate one month of physiological degradation. Results: Prototypes with multilayered cores demonstrated high stiffness but excessive needle resistance (>2 N). The optimal configuration, Model 17, featured a single-layer 1:1 PLA–PCL copolymer core reinforced with PGA felt and enclosed within a microporous 1:1 PLA–PCL sheath. This design achieved an initial S–L deviation of 0.75 ± 0.41 mm under single loading, a cyclic deviation of 2.06 ± 0.13 mm, and needle penetration resistance of 1.11 N, ensuring adequate rigidity and surgical usability. Following 28 days of PBS immersion, mechanical stability was retained (0.79 ± 0.28 mm deviation), confirming structural resilience during early remodeling. Conclusions: The proposed bioabsorbable semi-rigid annuloplasty ring offers an effective balance of strength, flexibility, and controlled degradation, addressing key limitations of current pediatric devices. Model 17 demonstrated superior mechanical and handling characteristics, suggesting strong potential for pediatric AVV repair and warranting further in vivo evaluation to confirm long-term safety, tissue integration, and functional performance. |
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| 言語 | en | |||||||||||||
| 書誌情報 |
ja : 金沢医科大学雑誌 en : Journal of Kanazawa Medical University 巻 51, 号 1, p. 22-26, 発行日 2026-03 |
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| 出版者 | ||||||||||||||
| 出版者 | 金沢医科大学医学会 | |||||||||||||
| 言語 | ja | |||||||||||||
| ISSN | ||||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||||
| 収録物識別子 | 24366994 | |||||||||||||
| 著者版フラグ | ||||||||||||||
| 出版タイプ | VoR | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||
