| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-03-29 |
| タイトル |
|
|
タイトル |
Hemophagocytic Lymphohistiocytosis during the Treatment of T-lymphoblastic Lymphoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
hemophagocytosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
lymphohistiocytosis |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
T-lymphoblastic lymphoma |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.57457/0002000127 |
|
ID登録タイプ |
JaLC |
| 著者 |
岡田 直樹
藤澤 麗子
犀川 太
佐藤 仁志
|
| 著者（英） |
|
|
|
姓名 |
Naoki Okada |
|
|
言語 |
en |
| 著者（英） |
|
|
|
姓名 |
Reiko Fujisawa |
|
|
言語 |
en |
| 著者（英） |
|
|
|
姓名 |
Yutaka Saikawa |
|
|
言語 |
en |
| 著者（英） |
|
|
|
姓名 |
Hitoshi Sato |
|
|
言語 |
en |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
A 12-year-old Japanese boy presented with epigastric pain and swelling of the neck. Biopsy of the cervical lymph node and the bone marrow showed diffuse proliferation of lymphoblastic cells with precursor T-cell immunophenotypes. The patient was diagnosed with stage IV T-lymphoblastic lymphoma (T-LBL) and complete remission was successfully achieved after induction chemotherapy without any adverse events. At 10 months after diagnosis, he presented with an abrupt onset of transfusion-refractory thrombocytopenia during maintenance therapy. Bone marrow examinations revealed hypoplastic marrow with phagocytosis of the blood cells by multinucleated giant cells with foamy cytoplasm and a diagnosis of hemophagocytic lymphohistiocytosis (HLH) was confirmed. No evidence of T-LBL relapse was found by positron emission tomography. He progressed to severe bone marrow failure and underwent allogeneic stem cell transplantation (SCT) from his human leukocyte antigen (HLA)-matched brother. He achieved complete remission with partial hematological recovery. Unfortunately, the patient died from relapsed T-LBL at 6 months after SCT. The onset of HLH during childhood cancer therapy is extremely rare, but these conditions often develop chemoresistance resulting in a lethal outcome. Therefore, they may require more intensive myeloablative therapy with stem cell rescue. |
|
言語 |
en |
| 書誌情報 |
巻 49,
号 1,
p. 35-37,
発行日 2024-03
|
| 出版者 |
|
|
出版者 |
金沢医科大学医学会 |
|
言語 |
ja |
| ISSN |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
2436-6994 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
本文 (1.7 MB)
